LRUE Fièvre Aphteuse

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The European Union Reference Laboratory organises Proficiency Tests (PTs) on detection and typing of Foot-and-Mouth disease virus in accordance with the Regulation (EU) No 2017/625.

PT panels for FMDV and SVDV detection are established for virus isolation, RT-PCR, Antigen-ELISA and VP1 sequencing. PT panels for FMD antibody detection are established for FMDV NSP antibodies, FMDV SP antibodies and SVDV antibodies detection by ELISAs or/and virus neutralisation test.

The proficiency test (PT) for FMD virus and SVD virus and antibody detection is organised annually. All EU national reference laboratories (NRLs) and other official laboratories of the network are invited to participate.

Intro [EN]: 

The European Union Reference Laboratory yearly organizes a workshop, especially intended for the EU national reference laboratories (NRLs) and other official laboratories of the network.

The purpose of these workshops is to inform the participants about the activities of the EURL, to present and discuss the results of the PT, to present and discuss scientific research projects and to exchange information on EU legislation, methods and other relevant subjects.


 Registration to the next workshop

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The EURL for FMD, among other missions, gathers data and information on the methods of diagnosis and differential diagnosis used in the different National Laboratories.

A list of methods inspired by the OIE official methods is available on this website.

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The EURL for FMD supports the functions of National Laboratories by storing and supplying reagents and materials for use in diagnosis of foot-and-mouth disease such as virus and/or inactivated antigens, standardised sera, cell lines and other reference reagents.

A list of reagents and material is available on this website.

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Foot-and-Mouth disease
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Réactifs disponibles et matériaux de référence
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Available reagents and reference materials
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Accueil LRUE FA
Intro [EN]: 

The European Union Reference Laboratory organizes each year trainings specifically intended for the EU national reference laboratories (NRLs) and other official laboratories of the network.

The purpose of these sessions is to implement the further training of experts in laboratory diagnosis with the goal to harmonize the diagnostic techniques at the European and International levels.

Registration to the next training


Bulgarian Food Safety Agency,NDRVMI


Opening of EURL FMD website

Welcome to the website of the European Union Reference Laboratory for foot-and-mouth disease (EURL FMD).

The consortium between ANSES (France) and Sciensano (Belgium) is designated as the European Union Reference Laboratory for foot-and-mouth disease.

You will find on the site all the activities of the EURL and information related to FMD. It is accessible to all members of the network. Thank you for registering to have access to the private area.




Foot-and-mouth Disease


Foot-and-mouth disease (FMD) is a highly contagious viral disease affecting domesticated and wild cloven-hooved animals. FMD, a significant threat in terms of animal health, is one of the priority infectious diseases notifiable to the World Organisation for Animal Health (OIE). It is the most economically important disease affecting livestock. The disease is characterized by fever, lameness and the appearance of vesicular lesions in the mouth, on the tongue and on the muzzle, feet and sometimes on the teats. The responsible virus, foot-and-mouth disease virus (FMDV), is an Aphthovirus belonging to family Picornaviridae. There are seven FMDVs immunologically distinct serotypes (O, A, Asia 1, C, SAT 1, SAT 2 and SAT 3) with multiple subtypes within each serotype.

The disease is endemic in Africa, Middle-East, South-Asia and in Venezuela in South-America. Europe is free of FMD. However, disease-free countries are not immune to incursions of the disease from neighbouring or even distant infected countries. FMD may cause devastating economic losses for the affected country due to high costs for disease control and international trade embargoes.

To face this threat, a global control strategy was initiated in 2009 by the Food and Agriculture Organization of the United Nations (FAO) and the OIE, as part of the "Global Framework for the Progressive Control of Transboundary Animal Diseases" signed by the two partners in 2004. This global control strategy against foot-and-mouth disease is regarded as an international priority.

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French Agency for Food, Environmental and Occupational Health & Safety

14 rue Pierre et Marie Curie

94701 MAISONS-ALFORT cedex

Tel.: +33 (0)


Publication Director: Roger Genet, General Director of ANSES

Site technical administrator: Olivier Cohen

Site scientific administrators: Labib Bakkali Kassimi; Anthony Relmy



French Agency for Food, Environmental and Occupational Health & Safety

14 rue Pierre et Marie Curie

94701 MAISONS-ALFORT cedex

Tel.: +33 (0)


Personal data

ANSES, represented by its Director General, has responsibility for the processing of personal data intended for managing the reference activities of the ANSES foot-and-mouth disease laboratory (EURL FMD). The Data Protection Officer is the Director of Legal Affairs ( Personal data accessible via an authenticated connection and available for information are never divulged to third parties. In accordance with the provisions of the General Data Protection Regulation (GDPR) and the French Data Protection Act of 6 January 1978, as amended, you have a right to access and rectify any information that concerns you. You can also, for any legitimate reason, object to the processing of any data concerning you. You can exercise your rights by contacting:


Intellectual property

The EURL FMD website is the property of ANSES and is entirely covered by French and international legislation on intellectual property. All rights are reserved, including those of reproduction, distribution and transmission. Any use of the information contained on the site, regardless of its form, and particularly texts, photographs and diagrams, is subject to ANSES's prior authorisation.


Establishment of links
Any public or private site – with the exception of sites disseminating information that is illegal or of a particularly polemic, pornographic, sectarian or xenophobic nature – may, without prior authorisation, establish a link to the home page or directly to the information distributed by the EURL FMD website. However, under no circumstances shall the pages of the EURL FMD website ( be embedded within the pages of another site. All efforts shall be made to indicate clearly to the user that they are visiting the EURL FMD website and to enable them to browse freely.

In other cases, and particularly:

- if the site content is to be integrated into the navigation of the requesting site,

- if access to the pages containing the link to the EURL FMD website is not free of charge, a request for authorisation must be submitted to ANSES via


ANSES reserves the right to request the removal of a link that it considers does not comply with its editorial policy or may harm its image, without prejudice to any subsequent actions before the competent courts.

For its part, ANSES establishes links only on public websites and shall not be liable for any links towards its own site.

However, if you create a link to the EURL FMD website we ask you to inform us


Photographic credits

Credit: iStock, AdobeStock.

The photos are not free of copyright.


Web credits

The EURL FMD website was developed by JOUVE.

Research projects

The BioPic team of Anses and the service for Exotic viruses and particular diseases of Sciensano carry out applied and fundamental research in the fields of:

a) host/pathogen interaction, b) diagnosis, c) molecular epidemiology and d) vaccine. The scientific projects aim to develop improved diagnostic methods for FMDV detection, characterization and differentiation from other vesicular disease viruses, to characterize the virus strains circulating in endemic countries, to improve understanding of the mechanisms of FMDV persistence and to assess new prophylactic and control methods including antiviral drugs and emergency vaccines.

PT EURL 2019

From 03 June 2019 to 31 July 2019

The PT 2019 was organized from June to July.

Inscription for the next PT will be available on website

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Austrian Agency for Health and Food Safety, Institute for Veterinary Disease Control - Mödling


Laboratory network members

The EURL co-operates with a network of national reference laboratories (NRLs) and other official laboratories.