Publications

2020

Model of persistent foot-and-mouth disease virus infection in multilayered cells derived from bovine dorsal soft palate

Hägglund S, Laloy E, Näslund K, Pfaff F, Eschbaumer M, Romey A, Relmy A, Rikberg A, Svensson A, Huet H, Gorna K, Zühlke D, Riedel K, Beer M, Zientara S, Bakkali Kassimi L, Blaise‐Boisseau S, J.F Valarcher. 2020 Transbound Emerg Dis.

doi:10.1111/tbed.13332

 

The antibody response induced FMDV vaccines in sheep correlates with early transcriptomic responses in blood

Jouneau L, Lefebvre DJ, Costa F, Romey A, Blaise-Boisseau S, Relmy A, Jaszczyszyn Y, Dard-Dascot C, Déjean S, Versillé N, Guitton E, Hudelet P, Curet M, De Clercq K, Bakkali Kassimi L, Zientara S, Klonjkowski B, Schwartz-Cornil I. 2020 NPJ Vaccines

doi: 10.1038/s41541-019-0151-3

 

FMD vaccine matching: Inter laboratory study for improved understanding of r1 values

Willems T, De Vleeschauwer A, Perez-Filgueira M, Li Y, Ludi A, Lefebvre D, Wilsden G, Statham B, Haas B, Mattion N, Robiolo B, Beascoechea Perez C, Maradei E, Smitsaart E, La Torre J, De Clercq K. 2020. J Virol Methods

doi: 10.1016/j.jviromet.2019.113786

 

Seroprevalence and molecular characterization of foot-and-mouth disease in Chad

Abdel-Aziz AI., Romey A., Relmy A., Gorna K., Laloy E., Métras R., Munoz F., Blaise-Boisseau S., Zientara S., Lancelot R., Bakkali Kassimi L.2020. Vet Med Sci.

Doi : 10.1002/vms3.206. PMID : 31845545

2019

 

Serological and molecular epidemiology of foot-and-mouth disease viruses in agro-pastoralist livestock herds in the kachia grazing reserve, Nigeria

Ehizibolo DO, De Vleeschauwer AR, Haegeman A, Lefebvre D, Nwosuh CI, Umoh JU, Okolocha EC, Kazeem HM, Van Borm S, De Clercq K. 2019. Transbound Emerg Dis.

doi: 10.1111/tbed.13182

 

Model of Persistent Foot-and-Mouth Disease Virus Infection in Multilayered Cells Derived from Bovine Dorsal Soft Palate

Hägglund S, Laloy E, Näslund K, Pfaff F, Eschbaumer M, Romey A, Relmy A, Rikberg A, Svensson A, Huet H, Gorna K, Zühlke D, Riedel K, Beer M, Zientara S, Bakkali-Kassimi L, Blaise-Boisseau S, Valarcher JF. 2019.Transbound Emerg Dis.

https://doi.org/10.1111/tbed.13332.

 

Proteogenomics Uncovers Critical Elements of Host Response in Bovine Soft Palate Epithelial Cells Following In Vitro Infection with Foot-And-Mouth Disease Virus

Pfaff F, Hägglund S, Zoli M, Blaise-Boisseau S, Laloy E, Koethe S, Zühlke D, Riedel K, Zientara S, Bakkali-Kassimi L, Valarcher JF, Höper D, Beer M, Eschbaumer M. 2019. Viruses 11 (1)

https://doi.org/10.3390/v11010053

2018

Reconstructing the Evolutionary History of Pandemic Foot-and-Mouth Disease Viruses: The Impact of Recombination within the Emerging O/ME-SA/Ind-2001 Lineage

Bachanek-Bankowska K, Di Nardo A, Wadsworth J, Mioulet V, Pezzoni G, Grazioli S, Brocchi E, Kafle SC, Hettiarachchi R, Kumarawadu PL, Eldaghayes IM, Dayhum AS, Meenowa D, Sghaier S, Madani H, Abouchoaib N, Hoang BH, Vu PP, Dukpa K, Gurung RB, Tenzin S, Wernery U, Panthumart A, Seeyo KB, Linchongsubongkoch W, Relmy A, Bakkali-Kassimi L, Scherbakov A, King DP, Knowles NJ.2018. Sci Rep 8 (1)

https://doi.org/10.1038/s41598-018-32693-8

 

Development and validation of a foot-and-mouth disease virus SAT serotype-specific 3ABC assay to differentiate infected from vaccinated animals

Chitray M, Grazioli S, Willems T, Tshabalala T, De Vleeschauwer A, Esterhuysen JJ, Brocchi E, De Clercq K, Maree FF. 2018. J Virol Methods

doi: 10.1016/j.jviromet.2018.02.006

 

A Canine Adenovirus Type 2 Vaccine Vector Confers Protection against Foot-and-Mouth Disease in Guinea Pigs

De Vleeschauwer Annebel R., Xiaocui Zhou, David J. Lefebvre, Annabelle Garnier, Fleur Watier, Charly Pignon, Sandrine A. Lacour, Stephan Zientara, Labib Bakkali-Kassimi, Kris De Clercq, Klonjkowski B. 2018. Vaccine 36 (16)

https://doi.org/10.1016/j.vaccine.2018.02.074

 

Complete Genome Sequences of Five Foot-and-Mouth Disease Viruses of Serotype A Isolated from Cattle in Nigeria between 2013 and 2015

Vandenbussche F, Mathijs E, Ularamu HG, Ehizibolo DO, Haegeman A, Lefebvre D, De Vleeschauwer AR, Van Borm S, De Clercq K. 2018. Genome Announc

doi: 10.1128/genomeA.00039-18

 

Outbreak investigations and molecular characterization of foot-and-mouth disease viruses circulating in south-west Niger

Souley Kouato B, Elliot FM, King DP, Hyera J, Knowles NJ, Ludi AB, Mioulet V, Matlho G, De Clercq K, Thys E, Marichatou H, Issa S, Saegerman C. 2018. Transbound Emerg Dis.

doi: 10.1111/tbed.12642

 

Safe and Cost-Effective Protocol for Shipment of Samples from Foot-and-Mouth Disease Suspected Cases for Laboratory Diagnostic

A.Romey, A. Relmy, K. Gorna, E. Laloy, S. Zientara, S. Blaise‐Boisseau, et L. Bakkali Kassimi. 2018. Transbound Emerg Dis. 65 (1)

https://doi.org/10.1111/tbed.12648

2017

Complete Genome Sequences of Four Foot-and-Mouth Disease Viruses of Serotype South African Territories 1 (SAT 1), Topotype X, Isolated from Cattle in Nigeria in 2015

Vandenbussche F, Mathijs E, Ularamu HG, Ehizibolo DO, Haegeman A, Lefebvre D, Lazarus DD, Wungak YS, De Vleeschauwer AR, Van Borm S, De Clercq K. 2017. Genome Announc

doi: 10.1128/genomeA.01065-17

 

Laboratory validation of two real-time RT-PCR methods with 5'-tailed primers for an enhanced detection of foot-and-mouth disease virus

Vandenbussche F, Lefebvre DJ, De Leeuw I, Van Borm S, De Clercq K. 2017. J Virol Methods

doi: 10.1016/j.jviromet.2017.04.014

 

Foot-and-mouth disease virus serotype SAT1 in cattle, Nigeria

Ehizibolo DO, Haegeman A, De Vleeschauwer AR, Umoh JU, Kazeem HM, Okolocha EC, Van Borm S, De Clercq K. 2017 Transbound Emerg Dis.

doi: 10.1111/tbed.12629

 

Detection and Molecular Characterization of Foot and Mouth Disease Viruses from Outbreaks in Some States of Northern Nigeria 2013-2015

Ehizibolo DO, Haegeman A, De Vleeschauwer AR, Umoh JU, Kazeem HM, Okolocha EC, Van Borm S, De Clercq K. 2017. Transbound Emerg Dis.

doi: 10.1111/tbed.12602

 

Genetic Characterization of Serotypes A and Asia-1 Foot-and-Mouth Disease Viruses in Balochistan, Pakistan, in 2011

A.Ullah, S. M. Jamal, A. Romey, K. Gorna, M. A. Kakar, F. Abbas, J. Ahmad, S. Zientara, et L. Bakkali Kassimi. 2017. Transbound Emerg Dis.64 (5)

https://doi.org/10.1111/tbed.12548

2016

A Tale of Tails: Dissecting the Enhancing Effect of Tailed Primers in Real-Time PCR

Vandenbussche F, Mathijs E, Lefebvre D, De Clercq K, Van Borm S. 2016. PLoS One

doi: 10.1371/journal.pone.0164463

 

Establishment and Validation of Two Duplex One-Step Real-Time RT-PCR Assays for Diagnosis of Foot-and-Mouth Disease

K.Gorna, A. Relmy, A. Romey, S. Zientara, S. Blaise-Boisseau, et L. Bakkali-Kassimi. 2016.J Virol Methods 235

https://doi.org/10.1016/j.jviromet.2016.03.020

 

A Refined Guinea Pig Model of Foot-and-Mouth Disease Virus Infection for Assessing the Efficacy of Antiviral Compounds

De Vleeschauwer AR, Lefebvre DJ, Willems T, Paul G, Billiet A, Murao LE, Neyts J, Goris N, De Clercq K. 2014. Transbound Emerg Dis.

doi: 10.1111/tbed.12255

2015

Establishment of Persistent Foot-and-Mouth Disease Virus (FMDV) Infection in MDBK Cells

Kopliku Lela, Anthony Relmy, Aurore Romey, Kamila Gorna, Stephan Zientara, Labib Bakkali-Kassimi, et Sandra Blaise-Boisseau. 2015. Arch Virol 160 (10)

 https://doi.org/10.1007/s00705-015-2526-8

 

The RNA template channel of the RNA-dependent RNA polymerase as a target for development of antiviral therapy of multiple genera within a virus family

van der Linden L, Vives-Adrián L, Selisko B, Ferrer-Orta C, Liu X, Lanke K, Ulferts R, De Palma AM, Tanchis F, Goris N, Lefebvre D, De Clercq K, Leyssen P, Lacroix C, Pürstinger G, Coutard B, Canard B, Boehr DD, Arnold JJ, Cameron CE, Verdaguer N, Neyts J, van Kuppeveld FJ. 2015. PLoS Pathog

doi: 10.1371/journal.ppat.1004733

2014

A thiazepino[4,5-a]benzimidazole derivative hampers the RNA replication of Eurasian serotypes of foot-and-mouth disease virus

Lefebvre DJ, De Vleeschauwer AR, Goris N, Van Borm S, Chimirri A, Monforte AM, Valdazo-Gonzalez B, King DP, Neyts J, De Clercq K. 2014. Biochem Biophys Res Commun.

doi: 10.1016/j.bbrc.2014.11.023

 

In vitro surrogate models to aid in the development of antivirals for the containment of foot-and-mouth disease outbreaks

Osiceanu AM, Murao LE, Kollanur D, Swinnen J, De Vleeschauwer AR, Lefebvre DJ, De Clercq K, Neyts J, Goris N. 2014. Antiviral Res.

doi: 10.1016/j.antiviral.2014.02.009

 

Application of a cell-based protease assay for testing inhibitors of picornavirus 3C proteases

van der Linden L, Ulferts R, Nabuurs SB, Kusov Y, Liu H, George S, Lacroix C, Goris N, Lefebvre D, Lanke KH, De Clercq K, Hilgenfeld R, Neyts J, van Kuppeveld FJ. 2014. Antiviral Res.

doi: 10.1016/j.antiviral.2013.12.012

 

Proof of concept for the inhibition of foot-and-mouth disease virus replication by the anti-viral drug 2'-C-methylcytidine in severe combined immunodeficient mice

Lefebvre DJ, De Vleeschauwer AR, Goris N, Kollanur D, Billiet A, Murao L, Neyts J, De Clercq K. 2014. Transbound Emerg Dis.

doi: 10.1111/tbed.12069

 

The use of serosurveys following emergency vaccination, to recover the status of "foot-and-mouth disease free where vaccination is not practised"

Paton DJ, Füssel AE, Vosloo W, Dekker A, De Clercq K. 2014. Vaccine

doi: 10.1016/j.vaccine.2014.10.064

 

First Isolation and Molecular Characterization of Foot-and-Mouth Disease Virus in Benin

K.Gorna, E. Houndjè, A. Romey, A. Relmy, S. Blaise-Boisseau, M. Kpodékon, C. Saegerman, F. Moutou, S. Zientara, et L. Bakkali Kassimi. 2014. Vet Microbiol 171 (1)

https://doi.org/10.1016/j.vetmic.2014.03.003